Dose Adjustment of Polymyxins for Renal Insufficiency
نویسندگان
چکیده
منابع مشابه
Dose Adjustment of Polymyxins for Renal Insufficiency
In a recent article, Garonzik et al. (4) importantly advanced our knowledge of the pharmacokinetics (PK) of colistin methanesulfonate (CMS) and the active drug that it forms, colistin. In their elegant population PK study of critically ill patients, the authors demonstrated that creatinine clearance (CLCR) significantly affects the total body clearance of CMS and colistin (4). It is important t...
متن کاملDose Adjustment of Polymyxins for Renal Insufficiency
In a recent article, Garonzik et al. (4) importantly advanced our knowledge of the pharmacokinetics (PK) of colistin methanesulfonate (CMS) and the active drug that it forms, colistin. In their elegant population PK study of critically ill patients, the authors demonstrated that creatinine clearance (CLCR) significantly affects the total body clearance of CMS and colistin (4). It is important t...
متن کاملDose adjustment of polymyxins for renal insufficiency.
In a recent article, Garonzik et al. (4) importantly advanced our knowledge of the pharmacokinetics (PK) of colistin methanesulfonate (CMS) and the active drug that it forms, colistin. In their elegant population PK study of critically ill patients, the authors demonstrated that creatinine clearance (CLCR) significantly affects the total body clearance of CMS and colistin (4). It is important t...
متن کاملRenal insufficiency in Ghanaian HIV infected patients: need for dose adjustment.
BACKGROUND Antiretrovirals (ARVs) could lead to clinically significant nephrotoxicity and as such will require dose adjustments in the presence of renal insufficiency. OBJECTIVE To explore renal function estimating equations as alternatives for glomerular filtration rate (GFR) measurement in a stable cohort of HIV-infected patients. METHOD In estimating renal insufficiency in Ghanaian HIV-i...
متن کاملDrug Dose Adjustment in Chronic Renal Diseases
The development of numerous drugs over the last two decades to a variety of diseases with significant benefits has paralleled increasing awareness of the adverse effects of these drugs. Majority of the drugs are eliminated by the kidneys. Therefore it is mandatory to make appropriate dosage modification when renal function deteriorates to prevent drug toxicity. Dosage modification tables of lar...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2011
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.05080-11